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Mineral Salts Low in Endotoxins

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LOW IN ENDOTOXIN GRADES

Low in Endotoxin Minerals in solution for medical injection

Endotoxins are lipopolysaccharides (LPS) from the cell wall of Gram-negative bacteria that are normally released after cell death or lysis. Lipopolysaccharides (LPS) are compounds consisting of fat (lipo) and sugar (polysaccharide) components. The endotoxins have a significant impact on bioproduction processes, as they can negatively affect upstream fermentation as well as downstream fill and finish. For example, endotoxins can massively affect tissue cultures by interfering with cell proliferation and cell function. In parenteral drug formulations, on the other hand, they are undesirable because endotoxins can cause mild to severe immune reactions, including fever and inflammation, and even death. Therefore, for a number of highly sensitive applications, it is of utmost importance to use Mineral Salts with a low endotoxin content.

APPLICATIONS OF LOW IN ENDOTOXIN MINERAL SALTS

  • Solutions for injections
  • Solutions for infusions
  • Solutions for inhalation
  • Solutions for parenteral nutrition
  • Solutions for
    • Dialysis
    • Peritoneal dialysis
    • Haemofiltration
    • Osmotherapy
  • Ophthalmic preparations
  • Biopharmaceuticals

Our Low in Endotoxin grades are produced in GMP-certified production facilities designed specifically for this purpose. Thus, our low endotoxin Mineral Salts are produced according to their sensitive applications under the strictest conditions including low endotoxin process water.
To meet the highest standards and ensure consistent high quality, validated chromogenic-kinetic Limulus Amebocyte Lysate (LAL) tests are used to quantify the endotoxin content of our products.

LOW IN ENDOTOXIN PRODUCTS

Acetates

  • Calcium Acetate
  • Magnesium Acetate 4-hydrate
  • Potassium Acetate, anhydrous
  • Sodium Acetate 3-hydrate
  • Zinc Acetate 2-hydrate

Aspartates

  • Magnesium DL-Aspartate 4-hydrate
  • Potassium DL-Aspartate 0.5 hydrate

Citrates

  • Monosodium Citrate anhydrous
  • Trisodium Citrate, anhydrous
  • Trisodium Citrate 2-hydrate

EDTA

  • Calcium Disodium EDTA
  • Disodium EDTA 2-hydrate

Glycerophospahtes

  • Sodium Glycerophosphate

Gluconates

  • Calcium Gluconate 1-hydrate
  • Magnesium Gluconate

Lactates

  • Sodium Lactate Solution; approx. 52 %; from L-Lactic Acid
  • Sodium Lactate Solution; approx. 60 %; from L-Lactic Acid

Phosphates

  • Tricalcium Phosphate
  • Monopotassium Phosphate
  • Dipotassium Hydrogen Phosphate
  • Monosodium Phosphate, anhydrous
  • Monosodium Phosphate 2-hydrate
  • Disodium Hydrogen Phosphate 2-hydrate
  • Disodium Hydrogen Phosphate 7-hydrate
  • Disodium Hydrogen Phosphate 12-hydrate

Succinates

  • Sodium Succinate, anhydrous
  • Sodium Succinate 6-hydrate

Sulfates

  • Magnesium Sulfate 7-hydrate
  • Sodium Sulfate, anhydrous

Additional products can be developed or lower endotoxin limits (LAL) can be met upon customer request

For more information of our low endotoxin products, please refer to the Mineral Salts Low in Endotoxins brochure.

www.lohmann4minerals.com